Chawnshang Chang
Dr. Chang’s research focuses on the Androgen Receptor (AR). His pioneer cloning of human and
rat Androgen Receptor (Science-1988) represents the landmark discovery in the androgen-AR field
that not only lead to identify the pathogenesis of Testicular Feminization Syndrome and SBMA
Neuron Diseases, but also allows Urologists for the first time to monitor the AR status of
processing prostate cancer and dissect the mechanisms for failure of androgen deprivation therapy.
Dr. Chang then discovered the first AR co-regulator (1996-PNAS) that lead to subsequent findings
of more than 100 such co-regulators and their function in the modulation of Androgen-AR
functions in various diseases. In 2002 Dr. Chang’s lab generated the first floxed AR mouse
(PNAS-2002) that deleted AR in a selective cell and identify the first compound (ASC-J9) that
selectively degraded AR in selective cells, that led to the development of first potential therapy to
selectively target AR in SBMA Neuro disease (Nature Medicine-2007), Neutropenia (JEM-2009),
bladder cancer (JNCI-2007), wound healing (JCI-2009) and hepatitis B-induced liver cancer
(Science-TM-2010). By knockout AR in individual cell of prostate, Dr. Chang’s lab then
discovered AR could function as suppressor to CK5-basal intermediate epithelial cell, as survivor
to CK-8 luminal epithelial cell and as proliferator to stromal cell. These findings of differential
AR function in individual cells of prostate not only help to explain why androgen deprivation
therapy via systematic suppression androgen would fail, it also helps to develop new drugs to
target AR in selective prostate cell to battle prostate cancer. Dr. Chang is founder of
AndroScience Corporation established at 2001. Dr. Chang published 500 papers with citation over
32,000 in the AR-Urology/Oncology/Endocrinology field and trained more than 200 Ph.D.
students/post Drs.; 100 of his trainees are now professors in various Universities.
15th August 2025
| Time | Session |
|---|---|
|
10:30
12:00
|
TICC - 3F Banquet Hall
|