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Submitted
Abstract
Does Postoperative Antibiotic Prophylaxis Reduce Urinary Tract Infection Rates After Holmium Laser Enucleation of the Prostate? A Randomized Prospective Clinical Trial
Moderated Poster Abstract
Clinical Research
Benign Prostate Hyperplasia and Male Lower Urinary Tract Symptoms: Minimally Invasive Surgery
Author's Information
10
No more than 10 authors can be listed (as per the Good Publication Practice (GPP) Guidelines).
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Canada
Hazem Elmansy hazem.mansy@rocketmail.com Northern Ontario School of Medicine, Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario, Canada Thunder Bay Canada -
Oksana Blahitko oksana.blahitko@tbh.net Northern Ontario School of Medicine, Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario, Canada Thunder Bay Canada -
Jill Skogberg skogberi@tbh.net Northern Ontario School of Medicine, Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario, Canada Thunder Bay Canada -
Amr Hodhod amrwuk@yahoo.co.uk King Abdulaziz Medical City, National Guard Hospitals Affairs Riyadh Bahrain -
Husain Alaradi husainisaalaradi@gmail.com Northern Ontario School of Medicine, Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario, Canada Thunder Bay Canada *
Saud Alhelal drsalhelal@gmail.com Northern Ontario School of Medicine, Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario, Canada Thunder Bay Canada -
Khaled Alotaibi dr-kf@windowslive.com Northern Ontario School of Medicine, Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario, Canada Thunder Bay Canada -
Ruba Abdul Hadi ruba.ahadi@gmail.com Northern Ontario School of Medicine, Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario, Canada Thunder Bay Canada -
Ahmed S. Zakaria aszakaria81@yahoo.com Northern Ontario School of Medicine, Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario, Canada Thunder Bay Canada -
Marawan M. El Tayeb marawan.eltayeb@bswhealth.org Baylor Scott and White Health Temple, Texas United States -
 
 
 
 
 
 
 
 
 
 
Abstract Content
We aimed to evaluate whether a 3-day course of antibiotics following holmium laser enucleation of the prostate (HoLEP) reduces the incidence of postoperative urinary tract infections (UTIs) in a randomized controlled trial (RCT).
We included 89 patients who underwent HoLEP using MOSES™ 2.0 technology between November 2023 and September 2024 in this ongoing RCT. Patients' preoperative parameters, including prostate characteristics, were assessed, and all had a negative preoperative urine culture. All participants were discharged with a scheduled urine culture to be performed on postoperative day 3 (POD 3), regardless of whether they exhibited UTI symptoms. Intraoperative parameters and perioperative outcomes, including hospital admission and the incidence of postoperative UTIs, were collected and analyzed. Outcome measures, including IPSS, QoL, Qmax, and PVR, were collected and analyzed at 1, 3, and 6 months, with PSA measured at 3 months.
The antibiotic and no-antibiotic groups consisted of 45 and 44 patients, respectively. There were no statistically significant differences in preoperative characteristics or intraoperative parameters between the two groups. On POD 3, twelve patients (26.7%) in the antibiotic group exhibited UTI symptoms, compared to 14 patients (31.8%) in the no-antibiotic group (p=0.34). However, only three patients (6.8%) in the antibiotic group had a positive urine culture on POD 3, compared to 6 patients (13.6%) in the no-antibiotic group (p=0.19). One patient in the no-antibiotic group presented to the emergency room (ER) with acute epididymoorchitis. At one-month follow-up, only one patient in the antibiotic group had a positive urine culture. Postoperative outcomes, including IPSS, QoL, Qmax, PVR, and PSA, were comparable between the two cohorts up to 6 months postoperatively.
The administration of postoperative antibiotic prophylaxis following HoLEP does not significantly reduce the incidence of UTIs. This clinical trial will provide valuable insights into the practice of prescribing postoperative antibiotics after HoLEP, potentially reducing unnecessary antibiotic use.
Holmium Laser Enucleation of the Prostate (HoLEP), antibiotic prophylaxis, urinary tract infection (UTI), randomized controlled trial (RCT), benign prostatic hyperplasia (BPH), postoperative outcomes, MOSES™ 2.0 technology, prostate surgery, IPSS (International Prostate Symptom Score), and quality of life (QoL).
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Patient demographics, preoperative, operative, and postoperative data (up to 6 months)
 
 
 
 
 
 
 
 
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Presentation Details