To develop and validate a prognostic nomogram in patients with bladder cancer who underwent radical cystectomy based on Asian population.

Data of 304 Bladder cancer patients who undergo radical cystectomy at Siriraj hospital (2012-2023) were include to this study. Data were randomly split into Training group (80% , N = 242) and Testing group (20% , N=62) . Cox regression analysis was use to identify prognostic factors and Kaplan‐Meier analysis to assess survival outcome. A nomogram predicting OSS was constructed. Its performance was validated by AUC, the receiver operating characteristic (ROC) curves, concordance index (C‐index).

The results show median OSS was 51 months . Multivariate analysis of the training group showed that Age , Preoperative GFR, type of diversion , N stage and Lympho-vascular invasion were significantly associated with overall survival. In Testing group, C‐index of the nomogram was 0.734(95%CI ,0.688 – 0.782). AUC of the nomogram were 0.793(95%CI ,0.723 – 0.864). Calibration plots for 1- ,3‐ and 5‐year OSS displayed good concordance.

The nomogram has the potential to provide an individualized prediction of overall survival in patients with bladder cancer. The nomogram is an easy tool to assist clinicians in optimizing the postoperative management.