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Submitted
Abstract
Correlation between inflammatory serum biomarkers and spontaneous stone passage in patients with ureteral stones
Non-Moderated Poster Abstract
Meta Analysis / Systematic Review
Endourology: Urolithiasis
Author's Information
4
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Taiwan
Yu-Hsin Chen w0e8n1d1y@gmail.com Cathay General Hospital Division of Urology, Department of Surgery Taipei Taiwan *
Shu-Han Chuang w0e8n1d1y@gmail.com Changhua Christian Hospital Division of Ophthalmology Taipei Taiwan -
Shih-Shiang Tung to27365765@hotmail.com Cathay General Hospital Division of Urology, Department of Surgery Taipei Taiwan -
Yen-Chieh Wang yenchieh61649@hotmail.com Cathay General Hospital Division of Urology, Department of Surgery Taipei Taiwan -
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Abstract Content
Ureteral stones are a common condition associated with significant medical and economic burdens. Management ranges from observation to surgery, but predictors of spontaneous ureteral stone passage (SSP) remain unclear. This study investigates the potential role of inflammatory serum biomarkers—C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and white blood cell count (WBC)—in predicting SSP.
A systematic search of PubMed, Embase, and the Cochrane Library was conducted for studies published before 2022. Observational studies assessing the association between inflammatory biomarkers and SSP were included. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated to compare biomarker levels between stone passers and non-passers.
Fourteen cohort studies involving 5,181 patients were included. Both CRP and NLR levels were significantly higher in the non-passer group (CRP: SMD = -1.399, 95% CI: -2.261 to -0.537, P = 0.001; NLR: SMD = -0.77, 95% CI: -1.335 to -0.205, P = 0.008). In contrast, WBC levels did not significantly differ between the two groups (SMD = -0.163, 95% CI: -0.529 to 0.203, P = 0.382).
Elevated levels of CRP and NLR were inversely associated with spontaneous ureteral stone passage, indicating their potential as prognostic biomarkers. Further research is needed to validate the predictive value of inflammatory serum markers in patients with ureterolithiasis.
Ureteral stone, Spontaneous stone passage (SSP), C-reactive protein (CRP), Neutrophil-to-lymphocyte ratio (NLR), White blood cell count (WBC), Inflammatory biomarkers, Ureterolithiasis, Meta-analysis, Predictive markers, Non-surgical management
https://storage.unitedwebnetwork.com/files/1237/bbffe8af09391d83ebd8765a51819397.png
Forest plot of standardized mean differences (SMDs) in C-reactive protein (CRP) levels between spontaneous stone passers (SSP [+]) and non-passers (SSP [−]) across included studies. Negative SMDs indicate higher CRP levels in the SSP (−) group. Each
https://storage.unitedwebnetwork.com/files/1237/88be3deca32ed7f7b5d4fb591ab0246c.png
Forest plot of standardized mean differences (SMDs) in neutrophil-to-lymphocyte ratio (NLR) between spontaneous stone passers (SSP [+]) and non-passers (SSP [−]). Negative SMDs indicate higher NLR levels in the SSP (−) group. Each horizontal line rep
https://storage.unitedwebnetwork.com/files/1237/89378d98aaf90df1f139f6db7eaf6f1d.png
Forest plot of standardized mean differences (SMDs) in white blood cell (WBC) count between spontaneous stone passers (SSP [+]) and non-passers (SSP [−]). The plot shows mixed results across studies, and the pooled estimate (diamond) indicates no sig
 
 
 
 
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