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Abstract

Abstract Title

Pneumothorax as an adverse event of Pazopanib

Presentation Type

Moderated Poster Abstract

Manuscript Type

Case Study

Abstract Category *

Oncology: Urethra/ Penis/ Testes/ Sarcoma/ Miscellaneous

Author's Information

Number of Authors (including submitting/presenting author) *

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Co-author 1

Taku Kato Fujita Health University Clinical laboratory Toyoake Japan -

Co-author 2

Hidetoshi Ehara Asahi University Hospital Urology Gifu Japan -

Co-author 3

Osamu Tanaka Asahi University Hospital Radiology Gifu Japan -

Co-author 4

Mikiko Matsuo Asahi University Hospital Pathology Gifu Japan -

Co-author 5

Shigeyuki Sugie Asahi University Hospital Pathology Gifu Japan -

Co-author 6

Shohei Toyota Asahi University Hospital Urology Gifu Japan *

Co-author 7

Co-author 8

Co-author 9

Co-author 10

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Co-author 16

Co-author 17

Co-author 18

Co-author 19

Co-author 20

Abstract Content

Introduction

Sarcomas could be treated with Pazopanib, which has an unique adverse event such as pneumothorax. We report a case of pneumothorax which was suspected to be caused by Pazopanib.

Materials and Methods

47-year-old male had a right flank pain and constipation and visited to our hospital in February, 2024. An abdominal ultrasonography, contrast-enhanced CT and MRI revealed a 7.4cm right adrenal tumor. 123I-MIBG scintigraphy revealed negative for a pheochromocytoma. According to the large size of the tumor, malignant adrenal primary tumor was suspected. He received an open adrenalectomy. The tumor aggressively invaded the liver and thought it impossible to radically remove the tumor out. But instead, we performed the tumor biopsy. The pathology of the specimen revealed immature leiomyosarcoma, he started to take oral Pazopanib 800mg once daily. The primary adrenal tumor response was partial response, however he developed pneumothorax on his left lung. We suspected it as an adverse event of Pazopanib.

Results

Conclusions

Pazopanib may cause an adverse event of pneumothorax

Keywords

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