To evaluate the safety and effectiveness of compound chamomile lidocaine gel in children undergoing circumcision.

A multicenter, randomized controlled cohort study was conducted on boys aged 8–18 years. Patients were recruited from three specialized pediatric hospitals and underwent circumcision. Participants were randomly assigned to receive postoperative wound treatment with saline alone or saline combined with compound chamomile lidocaine gel. The primary outcome was the degree of local edema one week after surgery. Secondary outcomes included maximum pain score (VAS) within 2 days postoperatively, wound healing scores, total wound healing time, cosmetic score and patient scale at 4 weeks.

A total of 180 patients were randomised into the study. In the per-protocol set, the incidence of moderate to severe edema in the intervention group was significantly lower than in the control group (10.59% Vs 24.10%). The VAS was also significantly lower in the intervention group compared to the control group (3.15±1.26 Vs 5.32±1.15), and the wound healing time was notably shorter（11.13±3.99 Vs 12.56±2.62）. No significant differences were observed for wound healing scores at 3, 7, and 14 days, cosmetic scores and patient scale at 4 weeks, or infection rates at 7 and 14 days. Three adverse events occurred in the control group and were resolved with outpatient treatment.

This study establishes that compound chamomile lidocaine gel serves as a safe and effective postoperative therapy for pediatric circumcision, highlighting its promising potential for clinical use.