Schwannomas, or neurilemmomas, are rare peripheral nerve sheath tumors, with penile involvement being exceptionally uncommon. Schwannomas of the external genitalia, especially the glans penis, are rarely reported. They are typically benign, slow-growing, and often associated with neurofibromatosis type 2 (NF2) gene mutations.

A 33-year-old male presented with a painless, slow-growing mass on the dorsal glans penis. Clinical examination revealed a well-circumscribed, mobile, nodular lesion with no signs of inflammation. Imaging with penile ultrasonography and contrast-enhanced multiplanar MRI confirmed a hypoechoic, vascular lesion distinct from the corpus cavernosum. Intraoperative frozen section analysis showed no malignant cells. Complete surgical excision was performed under general anesthesia.

Histopathological examination revealed a well-circumscribed spindle cell tumor with nuclear palisading and myxoid changes, consistent with schwannoma. Immunohistochemical staining showed strong and diffuse S-100 positivity, confirming the diagnosis. Postoperatively, erectile function was normal at 3 months, with no recurrence or progression over a follow-up of 4.5 years. Complete excision provided definitive treatment without oncological compromise.

Penile schwannomas are extremely rare tumors with a favorable prognosis. Their vascularity may lead to misdiagnosis as hemangiomas on ultrasonography. Contrast-enhanced MRI plays a crucial role in diagnosis and surgical planning. Given their potential occurrence at any site where nerves traverse, schwannomas should be considered in the differential diagnosis of penile masses, even in rare locations like the glans.