To retrospectively study the improvement of postoperative LUTS symptoms and related complications in patients with a history of TRUS-Bx who were treated with USP-HoLEP or TUVP surgery at different intervals after puncture.

From January 2022 to October 2024, 210 patients with clear BPH on pathologic examination after performing TRUS-Bx and then surgical treatment with USP-HoLEP or TUVP and 80 surgical patients with no history of puncture, totaling 290 patients, were collected for relevant study data. The patients were grouped according to the different time intervals between TRUS-Bx and surgical treatment, Group A: interval ≤2 weeks, Group B: interval >2 weeks and ≤4 weeks, Group C: interval >4 weeks. Surgery-related data and various follow-up data of patients in each group were compared and studied.

1、All 290 surgeries were successfully completed without serious complications. 2、TRUS-Bx caused a short-term increase in IPSS score and QoL score, as demonstrated by the patients' elevated preoperative IPSS scores and QoL scores (F=10.73, p<0.05). 3、Patients in groups A, B, and C with a history of TRUS-Bx all had more mean intraoperative bleeding than patients in group D without a history of puncture (F=5.68, P<0.05). 4、The length of the interval between TRUS-Bx and surgery mediated the effect by influencing the change in patients' preoperative IPSS scores and QoL scores (rho = -0.27, P < 0.005) patients' postoperative IPSS scores and QoL scores 1 week after removal of the urinary catheter (rho = 0.56). 5、The IPSS and QoL scores of patients in group A were higher than those in groups B, C, and D at 1 week after removal of urinary catheters (P < 0.05); at 1 month after removal of urinary catheters, the mean levels of IPSS scores and QoL scores were similar among the patients in the four study group (P > 0.05). 6、USP-HoLEP and TUVP had less intraoperative bleeding compared with those in treating patients in group A (P > 0.05).

1、TRUS-Bx can lead to elevated IPSS and QoL scores in patients in the short term, and the effect of a history of TRUS-Bx on IPSS and QoL scores disappeared after greater than 4 weeks; beginning 1 month after removal of the urinary catheter, the mean IPSS and QoL scores of patients in each group were close to each other. 2、Intraoperative bleeding was increased in patients with a history of TRUS-Bx compared with those without a history of puncture. 3、There was no significant difference in the incidence of postoperative urinary control-related complications between patients with and without a history of TRUS-Bx; 4、There was less intraoperative bleeding in the USP-HoLEP group than in the TUVP group when treating patients in the ≤2-week interval group.